Phasic Transmitter Release from Tonic Neurons
نویسندگان
چکیده
منابع مشابه
Phasic Transmitter Release from Tonic Neurons
Graded and prolonged presynaptic depolarizations trigger the tonic release of neurotransmitters from sensory neurons. In this issue of Neuron, Simmons reports that postsynaptic responses of locust interneuron synpapses are determined by the rate rather than the amplitude of presynaptic depolarization, suggesting a mechanism for increasing the signaling capabilities of this synapse with respect ...
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The paired phasic and tonic motor neurons supplying the extensor muscle in the crayfish leg were investigated to establish whether differences in synaptic structure could account for large differences in transmitter release at the neuromuscular junctions. Nerve terminals with transmitter release that had been assessed from recordings made with a focal "macro-patch" electrode were subsequently l...
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Synaptic functional differentiation of crayfish phasic and tonic motor neurons is large. For one impulse, quantal release of neurotransmitter is typically 100-1000 times higher for phasic synapses. We tested the hypothesis that differences in synaptic strength are determined by differences in synaptic calcium entry. Calcium signals were measured with the injected calcium indicator dyes Calcium ...
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Tonic and phasic dopamine release is implicated in learning, motivation, and motor functions. However, the relationship between spike patterns in dopaminergic neurons, the extracellular concentration of dopamine, and activation of dopamine receptors remains unresolved. In the present study, we develop a computational model of dopamine signaling that give insight into the relationship between th...
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1. We studied graded synaptic transmission in the fly photoreceptor-interneuron synapse by using intracellular in situ recordings from pre- and postsynaptic cells. 2. A large presynaptic hyperpolarization after light adaptation, caused by the activation of the electrogenic Na+/K+ pump, drastically reduced the conspicuous postsynaptic dark noise. At the same time, the postsynaptic neurons depola...
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ژورنال
عنوان ژورنال: Neuron
سال: 2002
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(02)00833-4